Douglas A. Kniss, Ph.D.
Professor
Education
B.S., Biology and Psychology, Susquehanna University, 1980
Ph.D., Anatomy and Cell Biology, The Ohio State University, 1986
Postdoctoral Fellowship, National Institutes of Health, 1987
Work Experience
Professor, Department of Obstetrics & Gynecology, College of Medicine
Professor, Department of Biomedical Engineering, College of Engineering
Member, Integrated Biomedical Graduate Program, College of Medicine
Member, Molecular, Cellular and Developmental Biology Graduate Program
Member, Ohio State University Nutrition Graduate Program
Honors and Awards
President's Poster Award, Society for Gynecologic Investigation, 1991
Contact Information
208 Bricker Hall,
190 North Oval mall,
Columbus, OH 43210
Phone: (614) 292-1582
Email: kniss.1@osu.edu
Professional Societies
- Society for Gynecologic Investigation
- American Society for Cell Biology
- Tissue Engineering Society International
- American Diabetes Association
- American Association for the Advancement of Science
- American Society for Microbiology
- International Federation of Placental Associations
- New York Academy of Sciences
- Perinatal Research Society
Research interests
Dr. Kniss is Director of the Laboratory of Perinatal Research within the Department of Obstetrics and Gynecology. Research interests in the lab include stem cell biology, tissue engineering, signal transduction and inflammation. Translational interests in the lab focus on understanding the role of inflammation and signaling pathways in the context of pregnancy complications and diabetes.
A second major focus of the lab involves studies into the influence of three-dimensional geometry within engineered tissue constructs on the differentiation of stem cell populations. In addition, collaborative studies are carried out with biomaterials engineers to evaluate the influence of surface nanotopography on cell adhesion, migration and differentiation. Research currently in progress in the lab focuses on understanding the molecular mechanisms that coordinate transcription factor function in the setting of inflammation.
In addition, studies are underway to examine the mechanisms by which stem cells interact with polymer surfaces for applications in tissue engineering.
Teaching
BME 694: "Fundamentals of Cell & Tissue Engineering"
Med I lecturer
Med II lecturer
Selected Publications
- Ackerman WE IV, Robinson JM, Kniss DA. In situ immunolabeling allows for detailed localization of prostaglandin synthesizing enzymes in amnion epithelium, Placenta 2005; doi: 10.1016/j.placenta.2005.06.009
- Xie Y, Kang X, Ackerman WE IV, Belury MA, Koster C, Rovin BH, Landon MB, and Kniss DA. Differentiation-dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandins, Diabetes, Obesity, and Metabolism 2005; 8(1): 83-90
- Ackerman WE IV, Robinson JM, Kniss DA. Despite transcriptional and functional coordination, cyclooxygenase-2 and microsomal prostaglandin E synthase-1 largely reside in discrete lipid domains in WISH epithelial cells, Journal of Histochemistry and Cytochemistry 2005; 53(11): 1391-1401
- Ackerman WE IV, Zhang XL, Rovin BH, and Kniss DA. Modulation of cytokine-induced cyclooxygenase 2 expression by PPARg ligands through NFkB signal disruption in human WISH and amnion cells, Biology of Reproduction 2005; 73(3): 527-35
- Kang X, Xie Y, Kniss DA. Adipose tissue model using three-dimensional cultivation of preadipocytes seeded onto fibrous polymer scaffolds, Tissue Engineering 2005; 11: 458-468
- Ackerman WE IV, Rovin BH, and Kniss DA. Epidermal growth factor and interleukin-1 utilize divergent signaling pathways to synergistically up-regulate cyclooxygenase-2 gene expression in human amnion-derived WISH cells, Biology of Reproduction 2004; 71:2079-86
- Li Y, Kniss DA, Lasky LC, and Yang S-T. Culturing and differentiation of murine embryonic stem cells in a three-dimensional fibrous matrix. Cytotechnology 2003; 41: 23-35
- Xie Y, Sproule T, Li Y, Powell H, Lannutti JJ, and Kniss DA. Nanoscale modifications of PET polymer surfaces via oxygen-plasma discharge yield minimal changes in attachment and growth of mammalian epithelial and mesenchymal cells in vitro. Journal of Biomedical Materials Research 2002; 61: 234-245
