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Mark A. Ruegsegger, Ph.D.
Clinical Assistant Professor

Education

BS, MS, Ph.D., Case Western Reserve University, Cleveland, Ohio

Contact Information

Rm. 292 Bevis Hall
1080 Carmack Road
Columbus, OH 43210

Phone: (614) 247-6890
Fax: (614)292-7301
Email: ruegsegger.1@osu.edu

Appointment

Joined BME & Cardiovascular Medicine Faculty in 2001

Research Interests

  • Blood compatibility of implantable polymeric devices
  • Protein-protein and cell-protein interactions
  • Surface modification and characterization
  • Peptide and saccharide synthesis and conjugation
  • Nanotechnology and drug delivery/imaging particles

Current Projects

  • Surface modification: Significant improvements in blood-contacting devices can be achieved by understanding nature's design and the application of biomimicry to artificial surfaces. Novel macromolecular structures derived from polymer synthesis and peptide/saccharide conjugation will afford a more blood compatible surface. The blood-compatible surfaces could then be applied to a variety of applications, including grafts, stents, or drug delivery vehicles.
  • Multi-platform Nanoparticles: Recent enhancements in Magnetic Resonance Imaging (MRI) techniques have led to increased resolution of anatomical structure and a greater potential for early diagnosis of organ and tissue pathologies. Nanotechnology approaches such as antibody-bound magnetic contrast agents will allow the targeting of diseased tissues and significant improvements in patient care. Hybrid nanostructures with both inorganic and biological components are being designed and tested to increase the resolving power of MRI to diagnosis cancer tissues.

Teaching

BME 600: Survey of Biomedical Engineering
Description: One of many lecturers who describe different aspects of Biomedical Engineering, including research and applicable principles.

BME 732: Soft Tissue Biomaterials
Description: Course focus is on chemistry, properties, and applications of soft (polymeric) biomaterials and their applications, with introduction to tissue engineering.

BME 739: Biopolymer Structure and Function
Description: Biological polymers are critical components for normal body function. Several key examples of biopolymers will be discussed in depth, including those involved in bone structure, coagulation, elasticity, extracellular matrix and genetics.

Selected Publications

  1. EH Anderson, MA Ruegsegger, G Murugesan, K Kottke-Marchant, RE Marchant, "Extracellular matrix-like surfactant polymers containing arginine-glycine-aspartic acid (RGD) peptides," Macromol Biosci 4, 766-775, 2004.
    2. SC Lee, MA Ruegsegger, M Ferrari, "Biological Molecules in Nanodevices" in Nanotechnology Handbook, HS Nalwa, ed., American Scientific Publishers, 2004.
  2. SC Lee, MA Ruegsegger, PA Barnes, BR Smith, M Ferrari, "Therapeutic Nanodevices" in Nanotechnology Encyclopedia, Bharat Bhushan, ed., Springer Verlag, 2004.
  3. G Murugesan, MA Ruegsegger, RE Marchant, K Kottke-Marchant, "Integrin-dependent interaction of human vascular endothelial cells on biomimetic peptide surfactant polymers," Cell Communication and Adhesion, 9(2), 59-73, 2002.
  4. MA Ruegsegger, RE Marchant, "Reduced protein adsorption and platelet adhesion by controlled variation of oligomaltose surfactant polymer coatings," Journal of Biomedical Materials Research 56 (2) 159-167 AUG 2001.
  5. NB Holland, Y Qiu, M Ruegsegger, RE Marchant, "Biomimetic engineering of non-adhesive glycocalyx-like surfaces using oligosaccharide surfactant polymers," Nature, 392 799-801, 1998.

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