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Ronald Xu, Ph.D.
Assistant Professor

Education

B.S., Precision Machinery and Instrumentation, University of Science and Technology of China, Hefei, China

M.S., Mechanical Engineering, State University of New York at Stony Brook, Stony Brook, NY

PhD., Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA

Professional Experience

Teaching Assistant, Department of Mechanical Engineering, State University of New York at Stony Brook, Stony Brook, NY. Advisor: Dr. Peisen Huang, 8/93-8/94

Research Assistant, Division of Instrumentation, Brookhaven National Lab, Upton, NY. Supervisor: Dr. Peter Takacs, 8/94-8/95

Research Assistant, Three Dimensional Printing Lab, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA. Advisor: Dr. Emanuel Sachs, 9/95-8/99

Postdoctoral Research Affiliate, Center for Design Research, Stanford University, Stanford, CA. Supervisor: Dr. Mark Cutkosky, 8/99-5/00

Director of Technology Development, ViOptix Inc, Fremont, CA, 1/00-9/04

Assistant Professor, Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 10/04-current

Contact Information

Rm. 286 Bevis Hall
1080 Carmack Rd.
Columbus, OH 43210
Phone: (614) 688-3635
Fax: (614) 292-7301
Email: xu.202@osu.edu

Affiliations

Member, Davis Heart & lung Research Institute (DHLRI)

Joint faculty member, Department of Electrical and Computer Engineering

Courtesy appointment, Department of Ophthalmology

Area of Expertise

Medical device design & innovation, biomedical imaging, tissue optics

Research Interests

  • Multi-modal, dynamic imaging of biological tissue in vivo

    We aim at developing a multi-modal imaging platform that integrates structural modalities (such as ultrasound) and functional modalities (such as near infrared spectroscopy) for real time, dynamic imaging of biological tissue in response to external stimuli (such as mechanical compression and venous/arterial occlusion).

  • Quantitative assessment of tissue oxygen dynamics and blood perfusion in vivo

    Tissue oxygen dynamics and its regulatory mechanisms under normal and abnormal conditions, is critical for effective detection and treatment of various diseases, including cancers, retinopathies and cardiovascular diseases. Recent developments in molecular biology have given us new insight into the cellular pathways of energy metabolism, as well as their integration to tissues and organs. However, existing imaging tools cannot provide a complete picture of tissue and cellular oxygen dynamics in vivo, which makes the quantitative analysis of metabolic pathways particularly challenging. We aim at understanding tissue oxygen dynamics by using multiple imaging modalities, developing macroscopic bioenergetic models, and exploring novel contrast agents.

Teaching

  • BME694 (Winter Quarter) Biomedical Optics

    Course Description: Introduction to clinical and technical aspects of biomedical optics, light transport in biological tissue, optical sources and detectors, biomedical applications of fiber optical components, optical imaging and spectroscopy on deep and superficial biological tissues.

  • BME694 (Spring Quarter) Medical Device Design, Fabrication and Regulatory

    Course Description: This course is designed to introduce essential processes involved in a medical device development cycle from concept to market. Through this course, students will learn: 1) how to convert clinical needs to product concepts, 2) design control, project planning and teamwork, 3) engineering tools for medical device design and fabrication, 4) human factors and ergonomics, 5) validation, quality control and FDA regulations, 6) Intellectual property management.

  • BME881 (Fall, Winter, Spring Quarters) Biomedical Engineering Seminar

    Two credits of BME 881 (6 quarters) are required for MS and PhD degrees in BME. Attendance of at least 6 out of 10 seminars in each quarter is required in order to get the credit. If you have registered BME 881 but fail to show up, you need to attend at least 6 biomedical related seminars in a quarter to get the credit. You need to submit a summary for each seminar listing: seminar title, location, time, presenter, brief notes, 1 sentence justification that the seminar is related to BME.

Selected Publications

  1. Xu, R. X. and S. P. Povoski (2007). "Diffuse optical imaging and spectroscopy for cancer." Expert Rev Med Devices 4(1): 83-95.
  2. Xu, R. and A. Rana (2006). "Dynamic Near Infrared Imaging with Ultrasound Guidance (dNIRUS): Analytical Model and Benchtop Validation on Multi-layer Tissue Simulating Phantoms." Proc. SPIE 6086: 353-364.
  3. Xu, R. X., S. P. Povoski, et al. (2006). "Near Infrared/Ultrasound Dual Modal Imaging for Breast Cancer Detection." Proc. SPIE 6081: 44-53.
  4. Xu, R., B. Qiang, et al. (2005). "Near infrared imaging of tissue heterogeneity: probe design and sensitivity analysis." Conf Proc IEEE Eng Med Biol Soc 1: 278-81.
  5. Xu, R., B. Qiang, et al. (2005). "Localization and functional parameter reconstruction of suspicious breast lesions by near infrared/ultrasound dual modal imaging." Conf Proc IEEE Eng Med Biol Soc 5: 4473-6.
  6. Xu, X., W. Zhu, et al. (2003). "Validation of NIRS In Measuring Tissue Hemoglobin Concentration And Oxygen Saturation Using Benchtop and Isolated Limb Model." Proc. SPIE 4955: 369-378.
  7. Cheng, X. and X. Xu (2003). "Study of the pressure effect in near infrared spectroscopy." Proc. SPIE 4955: 397-406.
  8. Xu, X. and E. Sachs (2001). "Conformal Cooling in Injection Molding." Journal of Polymer Science & Engineering 41(7).
  9. Huang, P. S. and X. Xu (1999). "Design of an Optical Probe for Surface Profile Measurement." Optical Engineering 38(7): 1223-1228.

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